Iduron

Iduron is a web based reagent company. All of our products can be viewed and purchased online at www.iduron. co.uk. We ship worldwide from our base in Manchester and offer 15% discount for orders over 1000GBP. Contact us for a quote or for any questions at info@iduron.co.uk. Place your order online, via email, fax or telephone and payt via credit card, bank transfer or cheque

Iduron was founded on peer-reviewed research at The University of Manchester, UK. We specialise in reagents and products for analysis of the structure and function of gylcosminoglycans (GAGs)

Idurons products

GAG Oligosaccharides
Relatively short sequences in GAGs dictate many of their biological properties. We specialise in the production and characterisation of GAG oligosaccharides.

Heparin Oligosaccharides
IdoA,2S – [GlcNS,6S – IdoA,2S] – GlcNS,6S
Characterised form dp4 – dp22. Dp 24 and dp26 sold with average molecular weights.

Hyaluronic Acid Oligosaccharides
GlcA – [GlcNAc – GlcA] - GlcNAc
Characterised form dp4 – dp20

Dermatan Sulphate Oligosaccharides
IdoA – [GalNAc,4S – IdoA] – GalNAc,4S
Characterised form dp4 – dp20

Glycosaminoglycans
Heparin, a chemical analogue of HS, enables efficient packaging of proteases in mast cell granules – clinically it is widely used as an anti-coagulant but other therapeutic applications of heparin are being investigated, for example its anti-inflammatory and anti-metastatic properties.

Dermatan Sulphate, Chondroitin Sulphate and Hyaluronic Acid
Mainly found in the extracellular matrix (ECM). They are important in maintaining the shape, hydration, elasticity and compressive resilience of the ECM but in addition they directly influence the activities of cells and tissues by controlling the transfer of growth factors to cell surfaces and, in the case of Hyaluronic Acid, by binding to specific receptors on the plasma membrane.

Heparan Sulphate (HS),
Structurally the most complex member of the GAG family, is a cell surface co-receptor for many growth and migration factors; HS is essential for the differentiation of embryonic stem cells and this critical requirement reflects its key role in transducing signals from morphogenic proteins such as Wnt/wingless, Hedgehog and neurotrophic factors such as GDNF, HB-GAM and midkine.
Some microbial pathogens and parasitic organisms bind to HS in the initial stages of infection of target cells.
We sell heparin, low molecular weight heparin, dermatan sulphate, Selectively Desulphated Heparins, Heperan Sulphate, Dermatan Sulphate and Low polydispersity HA polymers.

K5 Polysaccharides (Heparosan). Semi-synthetic Heparins and Heparans
Prepared from chemi-enzymatic modification of K5 polysaccharide (Heparosan).

Marine GAGS
Novel species of heparans, dermatans and chondroitins from organisms with high capacity for tissue regeneration Products includes disulphated dermatan sulphate (E-type) and low sulphated heparin and HS

Glycosaminoglycan degrading enzymes from Flavobacteria
Heparinase I
Heparinase II
Heparinase III
Chondroitinase B

Top quality, high activity preparations of purified stable enzymes supplied as sterile, frozen solutions.

Heparin and CS/DS Disaccharide Standards
For HPLC disaccharide analysis of your GAG

Heparin/GAG 96-well Binding Plates
Investigate GAG-protein interactions
Surface immobilisation of native glycosaminoglycans (GAGS) in a 96-well format.

• No modification of GAG necessary.
• Protein binding properties retained.
• Versatile and simple to use.
• Amenable to high throughput screening.
• Binds GAGs at room temperature using physiological buffers.
• Binds a wide range of GAGs; from fully sulphated heparin to non-sulphated hyaluronan from high molecular weight polysaccharides down to decasaccharides.

Swift Flow (SF) Heparin Affinity Gel and Pre-Packed Heparin-Affinity Columns.
Our Heparin Affinity Gel is based on a hydrophilic, high porosity, beaded cellulose matrix with ideal flow characteristics for rapid and efficient heparin-affinity chromatography. Chemical modification of the matrix provides excellent mechanical and chemical stability and, most importantly, minimises non-specific protein binding.

Heparin is covalently-bound to the gel at its reducing end by reductive amination; this stable linkage minimises leakage and enhances availability of active sites on the heparin for binding to proteins or other biological substances. Heparin density is approx. 4mg per ml of medium with a dynamic binding capacity equivalent to at least 20mg antithrombin per ml.